The growing wine in the area is very high, as the pleasures of the Nobile di Montepulciano wine have been known at least since the 8th century AD.
At the beginning of the 1800's Repetti in his 'Geographical, Physical and Historical Dictionary of Tuscany' mentioned an 'instrument' dated 17th October, 1350, in which in Montepulciano there was established a society of wine merchants

, showing evidence of that fact that the 'exquisite wine'of this area was exported from the area even in 'times past'. Sante Lancerio, the cellarman to the Farnese Pope, Paul III, in his book of travels about searching for the most esteemed wine for the Pope, in 1549, decreed Nobile 'the perfect wine, of noble men'.

But there was more importantly, the poet and doctor Francesco Redi who made famous, in the 17th century, the Nobile wine with his famous writing about 'Bacchus in Tuscany', in which he is ideally accompanied by Bacchus and Arianna in the examination of all the famous wines in Tuscany. Redi created the motto today everyone knows and which all the Poliziani use with pride: 'Montepulciano of all wines, is the king'. The adjective Nobile could have been derived from the fact that the wine was of superior quality and was in the past the exclusive prerogative of the noble families of the Montepulciano area. The Nobile di Montepulciano was one of the first Italian wines of a high quality and of an antique fame to obtain recognition with the denominazione di origine controllata (DOC) on the 12th July 1966, while being the first wine in Italy to receive the donominazione di origini controllata e garantita (DOCG) that decreed it one of the best wines of our country. Other wines of esteem produced in the area of the municipality are Rosso di Monetpulciano DOC, Bianco Vergine della Val di Chiana DOC, Chianti Colli Senesi DOC and also very esteemed and sought after Vin Santo DOC.